Allostatic load and disordered white matter microstructure in overweight adults.

ABSTRACT: Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlate

SUBMITTER: Ottino-Gonzalez J 

PROVIDER: S-EPMC6203765 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature