Optimization of carbon and energy utilization through differential translational efficiency.

ABSTRACT: Control of translation is vital to all species. Here we employ a multi-omics approach to decipher condition-dependent translational regulation in the model acetogen Clostridium ljungdahlii. Integration of data from cells grown autotrophically or heterotrophically revealed that pathways critical to carbon and energy metabolism are under strong translational regulation. Major pathways involved in carbon and energy metabolism are not only differentially transcribed and translated, but their translational efficiencies are differentially elevated in response to resource availability under different growth conditions. We show that translational efficiency is not static and that it changes dynamically in response to mRNA expression levels. mRNAs harboring optimized 5'-untranslated region and codi

SUBMITTER: Al-Bassam MM 

PROVIDER: S-EPMC6203783 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature