Improved methods for MRI-compatible implants in nonhuman primates.

ABSTRACT:

Background

Neuroscientists commonly use permanently implanted headposts to stabilize the head of nonhuman primates (NHPs) during electrophysiology and functional magnetic resonance imaging (fMRI). Here, we present improved methodology for MRI-compatible implants without the use of acrylic for head stabilization in NHPs.

New method

MRI is used to obtain a 3D-reconstruction of NHP skulls, which are used to create customized implants by modeling intersections with the bone. Implants are manufactured from PEEK using computer numerical control machining and coated with hydroxyapatite to promote osseointegration. Surgically, implants are attached to the skull with ceramic screws, while the skin flap is pulled over the implant and closed subcutaneously.

Results

Quality of bl

SUBMITTER: Ortiz-Rios M 

PROVIDER: S-EPMC6203806 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature