A protein functionalization platform based on selective reactions at methionine residues.

ABSTRACT: Nature has a remarkable ability to carry out site-selective post-translational modification of proteins, therefore enabling a marked increase in their functional diversity¹. Inspired by this, chemical tools have been developed for the synthetic manipulation of protein structure and function, and have become essential to the continued advancement of chemical biology, molecular biology and medicine. However, the number of chemical transformations that are suitable for effective protein functionalization is limited, because the stringent demands inherent to biological systems preclude the applicability of many potential processes². These chemical transformations often need to be selective at a single site on a protein, proceed with very fast reaction rates, operate under

SUBMITTER: Taylor MT 

PROVIDER: S-EPMC6203954 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature