The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients.

ABSTRACT:

Background

Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear whether the therapy could provide benefit for highly selected patients. Monocyte human leukocyte antigen (mHLA-DR) expression, a critical step in the immune response, is decreased during sepsis and leads to worsening sepsis outcomes. One recent study found that PMX-HP increased mHLA-DR expression while another found that the treatment removed HLA-DR-positive cells.

Methods

We conducted a randomized controlled trial in patients with blood endotoxin activity assay (EAA) level ≥ 0.6. Patients in the PMX-HP group received a 2-h PMX-HP treatment plus standard treatment for 2 consecutive days. Patients in the non-PMX-HP

SUBMITTER: Srisawat N 

PROVIDER: S-EPMC6204024 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature