Risk Evaluation of Azithromycin-Induced QT Prolongation in Real-World Practice.

ABSTRACT:

Background

Azithromycin exposure has been reported to increase the risk of QT prolongation and cardiovascular death. However, findings on the association between azithromycin and cardiovascular death are controversial, and azithromycin is still used in actual practice. Additionally, quantitative assessments of risk have not been performed, including the risk of QT prolongation when patients are exposed to azithromycin in a real-world clinical setting. Therefore, in this study, we aimed to evaluate the risk of exposure to azithromycin on QT prolongation in a real-world clinical setting using a 21-year medical history database of a tertiary medical institution.

Methods

We analyzed the electrocardiogram results and relevant electronic health records of 402,607 subjects in a ter

SUBMITTER: Choi Y 

PROVIDER: S-EPMC6204160 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature