Does colectomy affect the progression of primary sclerosing cholangitis? A systematic review and meta-analysis.

ABSTRACT:

Aim

The aim of this systematic review was to determine if the human colon, through the lower gut-liver axis, drives PSC activity by assessing the progression of the disease in patients with and without colectomy for colonic disease.

Background

The gut-liver axis is involved in the pathogenesis of liver disease. Abnormal immune-mediated responses to intestinal microbiome are implicated in primary sclerosing cholangitis (PSC) however the mechanisms remain poorly understood. Currently, no single animal model recapitulates all attributes of PSC in humans and this limits further studies of gut-liver interactions.

Methods

A systematic search of PubMed, Medline, and Scopus was performed for articles that contained the terms "colectomy" or "bowel resection" AND "primary scler

SUBMITTER: Ong J 

PROVIDER: S-EPMC6204254 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature