Reducing protein oxidation reverses lung fibrosis.

ABSTRACT: Idiopathic pulmonary fibrosis is characterized by excessive deposition of collagen in the lung, leading to chronically impaired gas exchange and death^1-3. Oxidative stress is believed to be critical in this disease pathogenesis^4-6, although the exact mechanisms remain enigmatic. Protein S-glutathionylation (PSSG) is a post-translational modification of proteins that can be reversed by glutaredoxin-1 (GLRX)⁷. It remains unknown whether GLRX and PSSG play a role in lung fibrosis. Here, we explored the impact of GLRX and PSSG status on the pathogenesis of pulmonary fibrosis, using lung tissues from subjects with idiopathic pulmonary fibrosis, transgenic mouse models and direct administration of recombinant Glrx to airways of mice with existing fibrosis. We dem

SUBMITTER: Anathy V 

PROVIDER: S-EPMC6204256 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature