Functional connectivity in cognitive control networks mitigates the impact of white matter lesions in the elderly.

ABSTRACT:

Background

Cerebrovascular pathology, quantified by white matter lesions (WML), is known to affect cognition in aging, and is associated with an increased risk of dementia. The present study aimed to investigate whether higher functional connectivity in cognitive control networks mitigates the detrimental effect of WML on cognition.

Methods

Nondemented older participants (≥ 50 years; n = 230) underwent cognitive evaluation, fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and resting state functional magnetic resonance imaging (fMRI). Total WML volumes were quantified algorithmically. Functional connectivity was assessed in preselected higher-order resting state networks, namely the fronto-parietal, the salience, and the default mode network, usi

SUBMITTER: Benson G 

PROVIDER: S-EPMC6204269 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature