Variability in metabolic parameters and risk of dementia: a nationwide population-based study.

ABSTRACT:

Background

Variability in biological parameters has been reported to be associated with adverse health outcomes. We aimed to investigate the composite effect of the visit-to-visit variability in blood pressure, glucose, cholesterol, and body mass index on the risk of dementia.

Methods

A population-based cohort study including 2,930,816 subjects without a history of dementia, hypertension, diabetes mellitus, and dyslipidemia who underwent ≥ 3 health examinations was performed. The coefficient of variation (CV), standard deviation, and variability independent of the mean were calculated as variability indices. High variability was defined as having values in the highest quartile for each parameter.

Results

A total of 32,901 (1.12%) participants developed dementia, of wh

SUBMITTER: Lee SH 

PROVIDER: S-EPMC6204276 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature