Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach.

ABSTRACT:

Background

Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resulting in its genome mutation and led to difficulties in creation of vaccine, drugs and treatment strategies. Vector control strategy has been a gold standard to combat spreading of CHIKV infection, but to eradicate a species from the face of earth is not an easy task. Therefore, alongside vector control, there is a dire need to prevent the infection through vaccine as well as through antiviral strategies.

Methods

This study was designed to find out conserved B cell and T cell epitopes of CHIKV structural proteins through immuno-informatics and computational a

SUBMITTER: Tahir Ul Qamar M 

PROVIDER: S-EPMC6204282 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature