Phase-amplitude coupling between interictal high-frequency activity and slow waves in epilepsy surgery.

ABSTRACT:

Objective

We hypothesized that the modulation index (MI), a summary measure of the strength of phase-amplitude coupling between high-frequency activity (>150 Hz) and the phase of slow waves (3-4 Hz), would serve as a useful interictal biomarker for epilepsy presurgical evaluation.

Methods

We investigated 123 patients who underwent focal cortical resection following extraoperative electrocorticography recording and had at least 1 year of postoperative follow-up. We examined whether consideration of MI would improve the prediction of postoperative seizure outcome. MI was measured at each intracranial electrode site during interictal slow-wave sleep. We compared the accuracy of prediction of patients achieving International League Against Epilepsy class 1 outcome between the fu

SUBMITTER: Motoi H 

PROVIDER: S-EPMC6204289 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature