Wdr13 and streptozotocin-induced diabetes.

ABSTRACT: Type I diabetes, though contributes to only 5-10% of total diabetes cases, is a rising concern in today's world. Our previous studies have shown that the absence of WDR13 in mouse results in pancreatic β-cell hyper-proliferation. Also, amelioration of the diabetic phenotype on introgression of Wdr13-null (Wdr13^-/0) mutation in genetically diabetic mice (Lepr^db/db) [type II diabetes] was observed. It was thus, interesting to see the role of WDR13 in streptozotocin-mediated diabetes in mice, a model for type I diabetes. Wdr13^-/0 mice along with its wild type (Wdr13^+/0 mice) littermates were administered streptozotocin intraperitoneally for 5 consecutive days. Blood glucose levels and body weights of these mice were monitored for subsequent 5 weeks

SUBMITTER: Mishra AP 

PROVIDER: S-EPMC6204428 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature