Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice.

ABSTRACT:

Background

Cancer cachexia occurs in approximately 80% of cancer patients and is a key contributor to cancer-related death. The mechanisms controlling development of tumour-induced muscle wasting are not fully elucidated. Specifically, the progression and development of cancer cachexia are underexplored. Therefore, we examined skeletal muscle protein turnover throughout the development of cancer cachexia in tumour-bearing mice.

Methods

Lewis lung carcinoma (LLC) was injected into the hind flank of C57BL6/J mice at 8 weeks age with tumour allowed to develop for 1, 2, 3, or 4 weeks and compared with PBS injected control. Muscle size was measured by cross-sectional area analysis of haematoxylin and eosin stained tibialis anterior muscle. ² H₂ O was used to

SUBMITTER: Brown JL 

PROVIDER: S-EPMC6204589 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature