Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease.

ABSTRACT:

Background

Chronic kidney disease (CKD) is commonly associated with cachexia, a condition that causes skeletal muscle wasting and an unfavourable prognosis. Although mechanisms leading to cachexia have been intensively studied, the advance of biological knowledges and technologies encourages us to make progress in understanding the pathogenesis of this disorder. Long noncoding RNAs (lncRNAs) are defined as >200 nucleotides RNAs but lack the protein-coding potential. LncRNAs are involved in the pathogenesis of many diseases, but whether they functionally involve in muscle protein loss has not been investigated.

Methods

We performed lncRNA array and identified an lncRNA, which we named Atrolnc-1, remarkably elevated in atrophying muscles from mice with cachexia. We examined ho

SUBMITTER: Sun L 

PROVIDER: S-EPMC6204593 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature