Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.

ABSTRACT:

Background

Glucocorticoids (GC) play a major role in muscle atrophy. As skeletal muscle is a secretory organ, characterization of the muscle secretome elicited by muscle atrophy should allow to better understand the cellular mechanisms and to identify circulating biomarkers of this condition. Our project aimed to identify the changes in the muscle secretome associated with GC-induced muscle atrophy and susceptible to translate into circulation.

Methods

We have identified the GC-induced changes in the secretome of C₂ C₁₂ muscle cells by proteomic analysis, and then, we have determined how these changes translate into the circulation of mice or human subjects exposed to high concentrations of GC.

Results

This approach led us to identify Serpina3n a

SUBMITTER: Gueugneau M 

PROVIDER: S-EPMC6204594 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature