Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty.

ABSTRACT:

Background

No regenerative approach has thus far been shown to be effective in skeletal muscle injuries, despite their high frequency and associated functional deficits. We sought to address surgical trauma-related muscle injuries using local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent cells (PLX-PAD), using hip arthroplasty as a standardized injury model, because of the high regenerative and immunomodulatory potency of this cell type.

Methods

Our pilot phase I/IIa study was prospective, randomized, double blind, and placebo-controlled. Twenty patients undergoing hip arthroplasty via a direct lateral approach received an injection of 3.0 × 10⁸ (300 M, n = 6) or 1.5 × 10⁸ (150 M, n = 7) PLX-PAD or a placebo (n = 7

SUBMITTER: Winkler T 

PROVIDER: S-EPMC6204595 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature