In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance.

ABSTRACT: Platinum drugs are widely used for cancer treatment. Other precious metals are promising, but their clinical progress depends on achieving different mechanisms of action to overcome Pt-resistance. Here, we evaluate 13 organo-Os complexes: 16-electron sulfonyl-diamine catalysts [(η⁶-arene)Os( N, N')], and 18-electron phenylazopyridine complexes [(η⁶-arene)Os( N, N')Cl/I]⁺ (arene = p-cymene, biphenyl, or terphenyl). Their antiproliferative activity does not depend on p21 or p53 status, unlike cisplatin, and their selective potency toward cancer cells involves the generation of reactive oxygen species. Evidence of such a mechanism of action has been found both in vitro and in vivo. This work appears to provide the first study of osmium complexes in the zebrafi

SUBMITTER: Coverdale JPC 

PROVIDER: S-EPMC6204601 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature