Bovine Staphylococcus aureus Superantigens Stimulate the Entire T Cell Repertoire of Cattle.

ABSTRACT: Superantigens (SAgs) represent a diverse family of bacterial toxins that induce Vβ-specific T cell proliferation associated with an array of important diseases in humans and animals, including mastitis of dairy cows. However, an understanding of the diversity and distribution of SAg genes among bovine Staphylococcus aureus strains and their role in the pathogenesis of mastitis is lacking. Population genomic analysis of 195 bovine S. aureus isolates representing 57 unique sequence types revealed that strains encode 2 to 13 distinct SAgs and that the majority of isolates contain 5 or more SAg genes. A genome-scale analysis of bovine reference strain RF122 revealed a complement of 11 predicted SAg genes, which were all expressed in vitro Detection of specific antibodies i

SUBMITTER: Wilson GJ 

PROVIDER: S-EPMC6204692 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature