Primary Role of Suppressor of Cytokine Signaling 1 in Mycobacterium bovis BCG Infection.

ABSTRACT: Suppressor of cytokine signaling 1 (SOCS1) is a negative regulator of JAK/STAT signaling and is induced by mycobacterial infection. To understand the major function of SOCS1 during infection, we established a novel system in which recombinant Mycobacterium bovis bacillus Calmette-Guérin expressed dominant-negative SOCS1 (rBCG-SOCS1DN) because it would not affect the function of SOCS1 in uninfected cells. When C57BL/6 mice and RAG1^-/- mice were intratracheally inoculated with rBCG-SOCS1DN, the amount of rBCG-SOCS1DN in the lungs was significantly reduced compared to that in the lungs of mice inoculated with a vector control counterpart and wild-type BCG. However, these significant differences were not observed in NOS2^-/- mice and RAG1^-/- NOS2^-/-<

SUBMITTER: Soma S 

PROVIDER: S-EPMC6204702 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature