Yeast and Filaments Have Specialized, Independent Activities in a Zebrafish Model of Candida albicans Infection.

ABSTRACT: Candida albicans dimorphism is a crucial virulence factor during invasive candidiasis infections, which claim the lives of nearly one-half of those afflicted. It has long been believed that filaments drive tissue invasion and yeast mediates bloodstream dissemination, but observation of these activities during infection has been prevented by technical limitations. We used a transparent zebrafish infection model to analyze more comprehensively how C. albicans utilizes shape to disseminate and invade. This model facilitated the use of diverse, complementary strategies to manipulate shape, allowing us to monitor dissemination, invasion, and pathogenesis via intravital imaging of individual fungal cells throughout the host. To control fungal cell shape, we employed three different strategies: g

SUBMITTER: Seman BG 

PROVIDER: S-EPMC6204735 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature