Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides.

ABSTRACT: Ethylenediamine-derived β-enamino amides are used as equivalents of amide enolate synthons in C-acylation reactions with N-protected amino acids. Domino fragmentation of the obtained intermediates leads to functionalised β-keto amides, bearing a protected amino group in their side chain.

SUBMITTER: Yanev P 

PROVIDER: S-EPMC6204755 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature