The impact of prophylactic dexamethasone on postoperative sore throat: an updated systematic review and meta-analysis.

ABSTRACT:

Background/aims

An updated systematic review and meta-analysis was conducted to assess the effect of prophylactic dexamethasone for tracheal intubation of general anesthesia on postoperative sore throat (POST).

Methods

Comprehensive literature search of databases for randomized controlled trials (RCTs), including Embase, PubMed, and Cochrane Library, which evaluate the effect of prophylactic dexamethasone on POST was conducted. RevMan 5.0 and STATA 12.0 software were used to perform meta-analyses.

Results

Fourteen RCTs totaling 1,837 patients were included for analysis. Compared with placebo, a significant reduction in the incidence of POST (OR 0.44, 95% CI 0.33-0.58, P<0.00001), hoarseness (OR 0.42, 95% CI 0.31-0.58, P<0.00001), and postoperative nausea

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC6204848 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature