CatSper channels are regulated by protein kinase A.

ABSTRACT: Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO₃ ^- concentration. This anion activates the atypical adenylyl cyclase Adcy10, increases intracellular cAMP, and stimulates protein kinase A (PKA). Moreover, an increase in intracellular Ca²⁺ concentration ([Ca²⁺] _i ) is essential for sperm capacitation. Although a cross-talk between cAMP-dependent pathways and Ca²⁺ clearly plays an essential role in sperm capacitation, the connection between these signaling events is incompletely understood. Here, using three different

SUBMITTER: Orta G 

PROVIDER: S-EPMC6204891 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature