Human CD4- invariant NKT lymphocytes regulate graft versus host disease.

ABSTRACT: Despite increasing evidence for a protective role of invariant (i) NKT cells in the control of graft-versus-host disease (GVHD), the mechanisms underpinning regulation of the allogeneic immune response in humans are not known. In this study, we evaluated the distinct effects of human in vitro expanded and flow-sorted human CD4⁺ and CD4^- iNKT subsets on human T cell activation in a pre-clinical humanized NSG mouse model of xenogeneic GVHD. We demonstrate that human CD4^- but not CD4⁺ iNKT cells could control xenogeneic GVHD, allowing significantly prolonged overall survival and reduced pathological GVHD scores without impairing human T cell engraftment. Human CD4^- iNKT cells reduced the activation of human T cells and their Th1 an

SUBMITTER: Coman T 

PROVIDER: S-EPMC6204997 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature