Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer's disease.

ABSTRACT:

Introduction

We investigated the effect of antihypertensive (aHTN) medications and cholinesterase inhibitors (ChEIs) on the cognitive decline in patients with Alzheimer's disease (AD) and analyzed synergism by chemogenomics systems pharmacology mapping.

Methods

We compared the effect of aHTN drugs on Mini-Mental State Examination scores in 617 AD patients with hypertension, and studied the synergistic effects.

Results

The combination of diuretics, calcium channel blockers, and renin-angiotensin-aldosterone system blockers showed slower cognitive decline compared with other aHTN groups (Δβ = +1.46, P < .0001). aHTN medications slow down cognitive decline in ChEI users (Δβ = +0.56, P = .006), but not in non-ChEI users (Δβ = -0.31, P = .53).

Discu

SUBMITTER: Hu Z 

PROVIDER: S-EPMC6205113 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature