Urinary LAM grade, culture positivity, and mortality among HIV-infected South African out-patients.

ABSTRACT:

Setting

Four ambulatory clinics in Durban, South Africa.

Objective

To test the relationships of patient characteristics, time to mycobacterial culture positivity, and mortality with urinary lipoarabinomannan (LAM) grade category.

Design

Newly diagnosed human immunodeficiency virus (HIV) infected adults were screened for tuberculosis (TB) using sputum culture, tested for urinary LAM, and followed for up to 12 months. We performed multivariable ordinal logistic regression of risk factors for low (1 or 2) or high (3, 4, or 5) LAM grade. We used adjusted Cox regression models to determine the hazard ratios of time to culture positivity and death.

Results

Among 683 HIV-infected adults, median CD4 count was 215 cells/mm³ (interquartile range 86-361 cells/mm³), 17% ha

SUBMITTER: Kubiak RW 

PROVIDER: S-EPMC6205186 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature