A Small Peptide Ac-SDKP Inhibits Radiation-Induced Cardiomyopathy.

ABSTRACT:

Background

Advances in radiotherapy for thoracic cancers have resulted in improvement of survival. However, radiation exposure to the heart can induce cardiotoxicity. No therapy is currently available to inhibit these untoward effects. We examined whether a small tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), can counteract radiation-induced cardiotoxicity by inhibiting macrophage-dependent inflammatory and fibrotic pathways.

Methods and results

After characterizing a rat model of cardiac irradiation with magnetic resonance imaging protocols, we examined the effects of Ac-SDKP in radiation-induced cardiomyopathy. We treated rats with Ac-SDKP for 18 weeks. We then compared myocardial contractile function and extracellular matrix by cardiac magnetic resonance imaging and th

SUBMITTER: Sharma UC 

PROVIDER: S-EPMC6205206 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature