Druggability of Coronary Artery Disease Risk Loci.

ABSTRACT:

Background

Genome-wide association studies have identified multiple loci associated with coronary artery disease and myocardial infarction, but only a few of these loci are current targets for on-market medications. To identify drugs suitable for repurposing and their targets, we created 2 unique pipelines integrating public data on 49 coronary artery disease/myocardial infarction-genome-wide association studies loci, drug-gene interactions, side effects, and chemical interactions.

Methods

We first used publicly available genome-wide association studies results on all phenotypes to predict relevant side effects, identified drug-gene interactions, and prioritized candidates for repurposing among existing drugs. Second, we prioritized gene product targets by calculating a drug

SUBMITTER: Tragante V 

PROVIDER: S-EPMC6205215 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature