No association between cardiometabolic risk and neural reactivity to acute psychosocial stress.

ABSTRACT:

Background

Exaggerated reactivity to acute psychosocial stress is associated with an increased risk of cardiovascular and metabolic disease. A dysfunction of the cortico-limbic network coordinating the peripheral adaptation to acute stress exposure may constitute a brain mechanism underlying this association. We opted to characterize the changes of this network associated with acute psychosocial stress exposure in individuals with low and high cardiometabolic risk (CMR).

Methods

In 57 subjects without overt cardiac or cerebral disease, the Framingham risk score and presence/absence of type 2 diabetes or metabolic syndrome defined CMR. Psychosocial stress was induced during functional magnetic resonance imaging (fMRI) of brain activity by an established social threat paradigm

SUBMITTER: Lederbogen F 

PROVIDER: S-EPMC6205354 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature