Relative contributions of lesion location and lesion size to predictions of varied language deficits in post-stroke aphasia.

ABSTRACT: Despite the widespread use of lesion-symptom mapping (LSM) techniques to study associations between location of brain damage and language deficits, the prediction of language deficits from lesion location remains a substantial challenge. The present study examined several factors which may impact lesion-symptom prediction by (1) testing the relative predictive advantage of general language deficit scores compared to composite scores that capture specific deficit types, (2) isolating the relative contribution of lesion location compared to lesion size, and (3) comparing standard voxel-based lesion-symptom mapping (VLSM) with a multivariate method (sparse canonical correlation analysis, SCCAN). Analyses were conducted on data from 128 participants who completed a detailed battery of psycholi

SUBMITTER: Thye M 

PROVIDER: S-EPMC6205357 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature