Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates.

ABSTRACT: Neutrophil extracellular traps (NETs) are involved in the pathogenesis of many infectious diseases, yet their dynamics and impact on HIV/SIV infection have not yet been assessed. We hypothesized that SIV infection and the related microbial translocation trigger NET activation and release (NETosis), and we investigated the interactions between NETs and immune cell populations and platelets. We compared and contrasted the levels of NETs between SIV-uninfected, SIV-infected, and SIV-infected antiretroviral-treated nonhuman primates. We also cocultured neutrophils from these animals with either peripheral blood mononuclear cells or platelets. Increased NET production was observed throughout SIV infection. In chronically infected animals, NETs were found in the gut, lung, and liver, and in the

SUBMITTER: Sivanandham R 

PROVIDER: S-EPMC6205390 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature