Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis.

ABSTRACT: Renin cells are crucial for survival - they control fluid-electrolyte and blood pressure homeostasis, vascular development, regeneration, and oxygen delivery to tissues. During embryonic development, renin cells are progenitors for multiple cell types that retain the memory of the renin phenotype. When there is a threat to survival, those descendants are transformed and reenact the renin phenotype to restore homeostasis. We tested the hypothesis that the molecular memory of the renin phenotype resides in unique regions and states of these cells' chromatin. Using renin cells at various stages of stimulation, we identified regions in the genome where the chromatin is open for transcription, mapped histone modifications characteristic of active enhancers such as H3K27ac, and tracked depositio

SUBMITTER: Martinez MF 

PROVIDER: S-EPMC6205391 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature