Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase.

ABSTRACT: Cross-over recombination products are a hallmark of meiosis because they are necessary for accurate chromosome segregation and they also allow for increased genetic diversity during sexual reproduction. However, cross-overs can also cause gross chromosomal rearrangements and are therefore normally down-regulated during mitotic growth. The mechanisms that enhance cross-over product formation upon entry into meiosis remain poorly understood. In Saccharomyces cerevisiae, the Superfamily 1 (Sf1) helicase Srs2, which is an ATP hydrolysis-dependent motor protein that actively dismantles recombination intermediates, promotes synthesis-dependent strand annealing, the result of which is a reduction in cross-over recombination products. Here, we show that the meiosis-specific recombinase Dmc1

SUBMITTER: Crickard JB 

PROVIDER: S-EPMC6205449 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature