Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory.

ABSTRACT: Stringent glucose demands render the brain susceptible to disturbances in the supply of this main source of energy, and chronic stress may constitute such a disruption. However, whether stress-associated cognitive impairments may arise from disturbed glucose regulation remains unclear. Here we show that chronic social defeat (CSD) stress in adult male mice induces hyperglycemia and directly affects spatial memory performance. Stressed mice developed hyperglycemia and impaired glucose metabolism peripherally as well as in the brain (demonstrated by PET and induced metabolic bioluminescence imaging), which was accompanied by hippocampus-related spatial memory impairments. Importantly, the cognitive and metabolic phenotype pertained to a subset of stressed mice and could be linked to early hy

SUBMITTER: van der Kooij MA 

PROVIDER: S-EPMC6205456 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature