The first single particle analysis Map Challenge: A summary of the assessments.

ABSTRACT: The recent successes of cryo-electron microscopy fostered great expectation of solving many new and previously recalcitrant biomolecular structures. However, it also brings with it the danger of compromising the validity of the outcomes if not done properly. The Map Challenge is a first step in assessing the state of the art and to shape future developments in data processing. The organizers presented seven cases for single particle reconstruction, and 27 members of the community responded with 66 submissions. Seven groups analyzed these submissions, resulting in several assessment reports, summarized here. We devised a range of analyses to evaluate the submitted maps, including visual impressions, Fourier shell correlation, pairwise similarity and interpretation through modeling. Unfortun

SUBMITTER: Heymann JB 

PROVIDER: S-EPMC6205511 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature