IDH1^R132H is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment.

ABSTRACT: Recurrent heterozygous mutation of isocitrate dehydrogenase 1 gene (IDH1), predominantly resulting in histidine substitution at arginine 132, was first identified in glioma. The biological significance of IDH1^R132H, however, has been controversial, and its prevalent association with glioma remains enigmatic. Although recent studies indicate that IDH1^R132H is nonessential to tumor growth or even anti-tumor growth, whether IDH1^R132H initiates gliomagenesis remains obscure. In this study, we report that IDH1^R132H is intrinsically tumor-suppressive but the activity can be attenuated by glutamate-the cerebral neurotransmitter. We observed that IDH1^R132H was highly suppressive of subcutaneous tumor growth driven by platelet-derived gr

SUBMITTER: Tiburcio PDB 

PROVIDER: S-EPMC6205547 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature