Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall survival.

ABSTRACT: Ovarian cancer is the most lethal gynecological malignancy in the western world. Despite recent efforts to characterize ovarian cancer using molecular profiling, few targeted treatment options are currently available. Here, we examined genetic variants, fusion transcripts, SNP genotyping, and gene expression patterns for early-stage (I and II) ovarian carcinomas (n=96) in relation to clinicopathological characteristics and clinical outcome, thereby identifying novel genetic features of ovarian carcinomas. Furthermore, mutation frequencies of specific genetic variants and/or their gene expression patterns were associated with histotype and overall survival, e.g. SLC28A2 (mucinous ovarian carcinoma histotype), ARCN1 (low expression in 0-2 year survival group), and tumor suppres

SUBMITTER: Engqvist H 

PROVIDER: S-EPMC6205557 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature