Studies of copper trafficking in a mouse model of Alzheimer's disease by positron emission tomography: comparison of ⁶⁴Cu acetate and ⁶⁴CuGTSM.

ABSTRACT: Alzheimer's disease can involve brain copper dyshomeostasis. We aimed to determine the effect of AD-like pathology on ⁶⁴Cu trafficking in mice, using positron emission tomography (PET imaging), during 24 hours after intravenous administration of ionic ⁶⁴Cu (Cu(ii) acetate) and ⁶⁴Cu-GTSM (GTSMH₂ = glyoxalbis(thiosemicarbazone)). Copper trafficking was evaluated in 6-8-month-old and 13-15 month-old TASTPM transgenic and wild-type mice, by imaging 0-30 min and 24-25 h after intravenous administration of ⁶⁴Cu tracer. Regional ⁶⁴Cu distribution in brains was compared by ex vivo autoradiography to that of amyloid-β plaque. ⁶⁴Cu-acetate showed uptake in, and excretion through, liver and kidneys. There was minimal uptake

SUBMITTER: Andreozzi EM 

PROVIDER: S-EPMC6205627 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature