Translation of combination nanodrugs into nanomedicines: lessons learned and future outlook.

ABSTRACT: The concept of nanomedicine is not new. For instance, some nanocrystals and colloidal drug molecules are marketed that improve pharmacokinetic characteristics of single-agent therapeutics. For the past two decades, the number of research publications on single-agent nanoformulations has grown exponentially. However, formulations advancing to pre-clinical and clinical evaluations that lead to therapeutic products has been limited. Chronic diseases such as cancer and HIV/AIDS require drug combinations, not single agents, for durable therapeutic responses. Therefore, development and clinical translation of drug combination nanoformulations could play a significant role in improving human health. Successful translation of promising concepts into pre-clinical and clinical studies requires early

SUBMITTER: Mu Q 

PROVIDER: S-EPMC6205718 | biostudies-literature | 2018 Jun - Jul

REPOSITORIES: biostudies-literature