MiR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy.

ABSTRACT:

Rationale

Abnormal SUMOylation has emerged as a characteristic of heart failure (HF) pathology. Previously, we found reduced SUMO1 (small ubiquitin-like modifier 1) expression and SERCA2a (sarcoplasmic reticulum Ca²⁺-ATPase) SUMOylation in human and animal HF models. SUMO1 gene delivery or small molecule activation of SUMOylation restored SERCA2a SUMOylation and cardiac function in HF models. Despite the critical role of SUMO1 in HF, the regulatory mechanisms underlying SUMO1 expression are largely unknown.

Objective

To examine miR-146a-mediated SUMO1 regulation and its consequent effects on cardiac morphology and function.

Methods and results

In this study, miR-146a was identified as a SUMO1-targeting microRNA in the heart. A strong correlation was observe

SUBMITTER: Oh JG 

PROVIDER: S-EPMC6205728 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature