Detection of tau in Gerstmann-Straussler-Scheinker disease (PRNP F198S) by [¹⁸F]Flortaucipir PET.

ABSTRACT: This study aimed to determine the pattern of [¹⁸F]flortaucipir uptake in individuals affected by Gerstmann-Sträussler-Scheinker disease (GSS) associated with the PRNP F198S mutation. The aims were to: 1) determine the pattern of [¹⁸F]flortaucipir uptake in two GSS patients; 2) compare tau distribution by [¹⁸F]flortaucipir PET imaging among three groups: two GSS patients, two early onset Alzheimer's disease patients (EOAD), two cognitively normal older adults (CN); 3) validate the PET imaging by comparing the pattern of [¹⁸F]flortaucipir uptake, in vivo, with that of tau neuropathology, post-mortem. Scans were processed to generate standardized uptake value ratio (SUVR) images. Regional [¹⁸F]flortaucipir SUVR was extracted and compared

SUBMITTER: Risacher SL 

PROVIDER: S-EPMC6205777 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature