DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births.

ABSTRACT:

Background

Placental inflammation, often presenting as acute chorioamnionitis (aCA), is commonly associated with preterm birth. Preterm birth can have both immediate and long-term adverse effects on the health of the baby. Developing biomarkers of inflammation in the placenta can help to understand its effects and potentially lead to new approaches for rapid prenatal diagnosis of aCA. We aimed to characterize epigenetic variation associated with aCA in placenta (chorionic villi) and fetal membranes (chorion and amnion) to better understand how aCA may impact processes that lead to preterm birth. This study lays the groundwork for development of novel biomarkers for aCA.

Methods

Samples from 44 preterm placentas (chorionic villi) as well as matched chorion and amnion for 16 o

SUBMITTER: Konwar C 

PROVIDER: S-EPMC6205793 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature