Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy.

ABSTRACT:

Background

Duchenne muscular dystrophy is a highly complex multi-system disease caused by primary abnormalities in the membrane cytoskeletal protein dystrophin. Besides progressive skeletal muscle degeneration, this neuromuscular disorder is also associated with pathophysiological perturbations in many other organs including the liver. To determine potential proteome-wide alterations in liver tissue, we have used a comparative and mass spectrometry-based approach to study the dystrophic mdx-4cv mouse model of dystrophinopathy.

Methods

The comparative proteomic profiling of mdx-4cv versus wild type liver extracts was carried out with an Orbitrap Fusion Tribrid mass spectrometer. The distribution of identified liver proteins within protein families

SUBMITTER: Murphy S 

PROVIDER: S-EPMC6205794 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature