The Ca²⁺ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations.

ABSTRACT: Conductances of ion channels and transporters controlling cardiac excitation may vary in a population of subjects with different cardiac gene expression patterns. However, the amount of variability and its origin are not quantitatively known. We propose a new conceptual approach to predict this variability that consists of finding combinations of conductances generating a normal intracellular Ca²⁺ transient without any constraint on the action potential. Furthermore, we validate experimentally its predictions using the Hybrid Mouse Diversity Panel, a model system of genetically diverse mouse strains that allows us to quantify inter-subject versus intra-subject variability. The method predicts that conductances of inward Ca²⁺ and outward K⁺ currents compensa

SUBMITTER: Rees CM 

PROVIDER: S-EPMC6205808 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature