Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial.

ABSTRACT:

Background

Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans.

Methods

We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014). Patients in the treatment group received perioperative oral curcumin (2000-mg doses 8 times over 4 d). Patients, health care providers an

SUBMITTER: Garg AX 

PROVIDER: S-EPMC6205831 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature