Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability.

ABSTRACT: Myelinated axons segregate the axonal membrane into four defined regions: the node of Ranvier, paranode, juxtaparanode, and internode. The paranodal junction consists of specific component proteins, such as neurofascin155 (NF155) on the glial side, and Caspr and Contactin on the axonal side. Although paranodal junctions are thought to play crucial roles in rapid saltatory conduction and nodal assembly, the role of their interaction with neurons is not fully understood. In a previous study, conditional NF155 knockout in oligodendrocytes led to disorganization of the paranodal junctions. To examine if disruption of paranodal junctions affects neuronal gene expression, we prepared total RNA from the retina of NF155 conditional knockout, and performed expression analysis. We found that the exp

SUBMITTER: Kunisawa K 

PROVIDER: S-EPMC6205917 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature