Methamphetamine dependence with and without psychotic symptoms: A multi-modal brain imaging study.

ABSTRACT:

Objective

Methamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with methamphetamine dependence who do, and do not, have psychosis. Two complementary imaging techniques were employed to investigate neurocircuitry associated with methamphetamine dependence with and without psychotic symptoms.

Methods

Three groups of participants were recruited: methamphetamine dependent (MAA) (N = 11), methamphetamine dependent with psychotic symptoms (MAP) (N = 14), and controls (N = 14). Resting brain glucose metabolism was measured using [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET) and cerebral perfusion was assess

SUBMITTER: Vuletic D 

PROVIDER: S-EPMC6205927 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature