Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.

ABSTRACT: Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are sorely needed to address these complex diseases. The metabotropic glutamate receptors are a class of G protein-coupled receptors that act to modulate neurotransmission across many brain structures. They have shown great promise as drug targets for numerous neurological and psychiatric diseases. Moreover, the development of subtype-selective allosteric modulators has allowed detailed studies of each receptor subtype. Here, we focus on the metabotropic glutamate receptor 7 (mGlu

SUBMITTER: Fisher NM 

PROVIDER: S-EPMC6206046 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature