Triggering Endogenous Cardiac Repair and Regeneration via Extracellular Vesicle-Mediated Communication.

ABSTRACT: A variety of paracrine signals create networks within the myocardium and mediate intercellular communications. Indeed, paracrine stimulation of the endogenous regenerative program of the heart, mainly based on resident cardiac progenitor cell (CPC) activation together with cardiomyocyte proliferation, has become increasingly relevant for future cardiac medicine. In the last years, it has been shown that extracellular vesicles (EV), including exosomes (Ex), are powerful conveyors of relevant biological effects. EV have been proposed not only as promising therapeutic tool for triggering cardiac regeneration and improving repair, but also as means of better understanding the physiological and pathological relationships between specific cardiac components, including cardiomyocytes and fibrobla

SUBMITTER: Bollini S 

PROVIDER: S-EPMC6206049 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature